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ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cells

Priyanka Verma, Yeqiao Zhou, Zhendong Cao, et al.

Downstream of gasdermin D cleavage, a Ragulator-Rag-mTORC1 pathway promotes pore formation and pyroptosis

Charles L. Evavold, Iva Hafner-Bratkovič, Jonathan C. Kagan

Discussion

Rab34 GTPase mediates ciliary membrane biogenesis in the intracellular ciliogenesis pathway

Anil Kumar Ganga, Margaret C. Kennedy, Mai E. Oguchi, et al.

Discussion

High-throughput discovery and characterization of human transcriptional effectors

Josh Tycko, Nicole DelRosso, Gaelen T. Hess, et al.

Genome-wide crispri/a screens in human neurons link lysosomal failure to ferroptosis

Ruilin Tian, Anthony Abarientos, Jason Hong, et al.

High-content Imaging-based Pooled crispr screens in Mammalian Cells

Xiaowei Yan, Nico Stuurman, Susana A. Ribeiro, et al.

AND

Image-based pooled whole genome crispr screening for Parkin and TFEB subcellular localization

Gil Kanfer, Shireen A. Sarraf, Yaakov Maman, et al.

Guide RNA categorization enables target site choice in Tn7-crispr-Cas transposons

Michael T. Petassi, Shan-Chi Hsieh, Joseph E. Peters

Neural plate targeting by in utero nanoinjection (NEPTUNE) reveals a role for Sptbn2 in neurulation and abdominal wall closure

Katrin Mangold, Jan Mašek, Jingyan He, et al.

Discussion

A subcellular atlas of Toxoplasma reveals the functional context of the proteome

Konstantin Barylyuk, Ludek Koreny, Huiling Ke, et al.

Organoid Easytag: an efficient workflow for gene targeting in human organoids

Dawei Sun, Lewis D. Evans, Emma L. Rawlins

The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics

Andrea Serra-Marques, Ronja Houtekamer, Dorine Hintzen, et al.

AND

NuMA interaction with chromatin is vital for proper nuclear architecture in human cells

Ashwathi Rajeevan, Riya Keshri, Sachin Kotak

A transient crispr/Cas9 expression system for genome editing in Trypanosoma brucei.

Sebastian Shaw, Sebastian Knüsel, Sarah Hoenner, et al.